Regenerative Cell Therapies in the News

  1. 'World Anti-Doping Agency (WADA) allows stem cell therapy to be used to treat injuries in athletes'
  2. 'Cristiano Ronaldo undergoes stem cell treatment for thigh injury'
  3. 'USA Basketball team doctor observes faster healing rates and athletes who have avoided surgery as a result of using stem cell injections'
  4. 'Rafael Nadal receives stem cell treatment for back injury'
  5. 'PRP significantly reduces knee pain'
  6. 'Celebrities turn to stem cell therapy'
  7. 'Are stem cells ace for tennis players?'

Clinical Evidence

  1. Slynarski K, et al: Treatment of Osteoarthritis: Adipose Derived Stem Cell & PRP Therapy. Sportärztezeitung March 2017
  2. Dai WL, et al: Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. Arthroscopy: The Journal of Arthroscopic and Related Surgery. 2016.
  3. Michalek J, et al: Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis. Cell Transplantation. 2015
  4. Nguyen P, et al: Comparative Clinical Observation of Arthroscopic Microfracture in the Presence and Absence of a Stromal Vascular Fraction Injection for Osteoarthritis. Stem Cells Translational Medicine. 2016;5:1-9
  5. Mazzocca A, et al: The positive effects of different platelet-rich plasma methods on human muscle, bone and tendon cells. The American Journal of Sports Medicine. 2012; 40(8): 1742-9.
  6. Smith PA: Intra-articular Autologous Conditioned Plasma injections provide safe and efficacious treatment for knee osteoarthritis. The American Journal of Sports Medicine. 2016; 44(4): 884-91.
  7. Centeno C, et al: A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomised controlled trial with two-year follow-up. Journal of Translational Medicine. 2018; 16:355
  8. Bansal H, et al: Intra-articular injection in the knee of adipose-derived stromal cells (stromal vascular fraction) and platelet-rich plasma for osteoarthritis. Journal of Translational Medicine. 2017; 15:14
  9. Kim J, Lee G, Jung G et al. Outcome of Autologous Bone Marrow Aspirates Concentrate Injection in Degenerative
    Arthritis of the Knee. Eur J Orthop Surg Traumatol. 2014;24(1):505–1511.
  10. Oliver K, Alexander RW. Combination of Autologous Adipose-Derived Tissue Stromal Vascular Fraction Plus High Density Platelet-Rich Plasma or Bone Marrow Concentrates in Achilles Tendon Tears. J of Prolotherapy. 2013;5:895-912
  11. Patel S, Dhillon S, Aggarwal S, Marwaha N, Jain A. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med. 2013;41(2):356-64.
  12. Oliver K, Bayes M, Crane D, C Pathikonda. Clinical Outcome of Bone Marrow Concentrate in Knee Osteoarthritis. Journal of Prolotherapy. 2015
  13. Görmeli G, Görmeli C, et al: Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double‑blind, placebo‑controlled trial. Knee Surg Sports Traumatol Arthroscopy. 2015
  14. Kuan-Yu Lin, et al: Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 35, No 1 (January), 2019: pp 106-117
  15. D. U. Jeong, et al: Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy. BioMed Research International Volume 2014, Article ID 249498, 15 pages
  16. Rachad Zayni, et al: Platelet-rich plasma as a treatment for chronic patellar tendinopathy: comparison of a single versus two consecutive injections. Muscles, Ligaments and Tendons Journal 92 2015;5 (2):92-98
  17. Ford RD, William P, Lineberry S, Luce P. A retrospective comparison of the management of recalcitrantlateral elbow tendinosis: platelet-rich plasma injections versus surgery. Hand (2015) 10:285–291
  18. Lebiedziński R, et al: A randomized study of autologous conditioned plasma and steroid injections in the treatment of lateral epicondylitis. International Orthopaedics (SICOT) 2015
  19. Jain K, Murphy P, Clough T. Platelet rich plasma versus corticosteroid injection for plantar fasciitis: A comparative study. The International Journal of Clinical Foot Science. (2015)
  20. Deans V, Miller A, Ramos J. A Prospective Series of Patients with Chronic Achilles Tendinopathy Treated with Autologous-conditioned Plasma Injections Combined with Exercise and Therapeutic Ultrasonography. The Journal of Foot & Ankle Surgery. 2012
  21. Hernigou P, et al: Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. Journal of Bone Joint Surgery Am. 2005 July;87(7):1430-7.
  22. Singh AK, et al: Percutaneous autologous bone marrow injections for delayed or non-union of bones. Journal of Orthopaedic Surgery. 2013 April;21(1):60-4.
  23. Desai P, et al: Bone Mesenchymal Stem Cells with Growth Factors Successfully Treat Nonunions and Delayed Unions. HSSJ (2015) 11:104–111
  24. Madry H, et al: Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects. Stem Cells International. Volume 2017, Article ID 1609685
  25. Darrow M, et al: Short-Term Outcomes of Treatment of Hip Osteoarthritis With 4 Bone Marrow Concentrate Injections: A Case Series. Clinical Medicine Insights: Case Reports. 2018 Volume 11: 1–5
  26. Shaw B, et al: Short-Term Outcomes in Treatment of Knee
    Osteoarthritis With 4 Bone Marrow Concentrate Injections. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders. 2018 Volume 11: 1–6
  27. Gorelick L, et al: Results of treatment of greater trochanteric pain syndrome in diabetic patients by single Hyaluronic Acid injection. International Journal of Humanities, Arts, Medicine and Sciences (BEST: IJHAMS). ISSN 2348-0521 Vol. 2, Issue 9, Sep 2014, 53-60
  28. Pogliacomi F, et al: When is indicated viscosupplementation in hip osteoarthritis? Acta Biomed. 2019; Vol. 90, Supplement 1: 67-74
  29. Rivera F. Single intra-articular injection of high molecular weight hyaluronic acid for hip osteoarthritis. Journal Orthopaedic Traumatology. Sept 2015
  30. Altman R, et al: Association between Hyaluronic Acid Injections and Time-to-Total Knee Replacement Surgery. Journal of Knee Surgery. October 2015
  31. Halpern B, et al: Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Clinical Journal of Sports Medicine. 2013; 23(3):238-9.
  32. Farr J, Cohen SB. Expanding Applications of the Subchondroplasty Procedure for Treatment of Bone Marrow Lesions Observed on Magnetic Resonance Imaging. Oper Tech Sports Med 2013; 21:138-143
  33. Frobell RB, Roos HP, Roos EM, Hellio Le Graverand MP, Buck R, Tamez-Pena J, Totterman S, Boegard T, Lohmander LS. The acutely ACL injured knee assessed by MRI: are large volume traumatic bone marrow lesions a sign of severe compression injury? Osteoarthritis and Cartilage 2008; 16:829-836
  34. Rosen MA, Jackson DW, Berger PE. Occult Osseous lesions Documented by Magnetic Resonance Imaging Associated with Anterior Cruciate Ligament Ruptures. Arthroscopy: The Journal of Arthroscopic and Related Surgery 1991; 7(1):45-51
  35. Cohen SB, Sharkey PF. Subchondroplasty for Treating Bone Marrow Lesions. J Knee Surg. 2016; 29(7):555-563
  36. Roemer FW, Neogi T, Nevitt MC, et al. Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study. Osteoarthritis Cartilage 2010; 18(1):47–53
  37. Wluka AE, Wang Y, Davies-Tuck M, English DR, Giles GG, Cicuttini FM. Bone marrow lesions predict progression of cartilage defects and loss of cartilage volume in healthy middle-aged adults without knee pain over 2 yrs. Rheumatology (Oxford) 2008; 47(9):1392–1396
  38. Felson DT, Chaisson CE, Hill CL, et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 2001; 134(7):541–549
  39. Tanamas SK, Wluka AE, Pelletier JP, et al. Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study. Rheumatology (Oxford) 2010; 49(12):2413–2419
  40. Niall DM, Bobic VB. Bone Bruising and Bone Marrow Edema Syndromes: Incidental Radiological Findings or Harbingers of Future Joint Degeneration? International Society of Arthroscopy, Knee Surgery, and Orthopaedic Sports Medicine.
  41. Smith RC, Constable RT, Reinhold C, McCauley T, Lange RC, McCarthy S. Fast Spin Echo STIR Imaging. Journal of Computer Assisted Tomography. 1994; 18(2):209-213
  42. Centeno C, Pitts J, Al-Sayegh H, Freeman M. Efficacy of autologous bone marrow concentrate for knee osteoarthritis with and without adipose graft. Biomed Research International. 2014;14:1-9.
  43. Filardo G, Madry H, Jelic M, Roffi A, Cuccchiarini M, Kon E. Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical applications in orthopaedics. Knee Surg Sports Traumatol Arthrosc. 2013;21:1717-1929.
  44. Huang J, Zuk P, Jones N, et al. Chondrogenic potential of multipotential cells from human adipose tissue. Plast. Reconstr. Surg. 2004;113(2):585-594.
  45. Kapoor M, Martel-Pelletierm J, Lajeunesse D, Pelletier J, Fahmi H. Role of pro-inflammatory cytokines in the pathophysiology of osteoarthritis. Nature Reviews Rheumatology. 2011;7:33-42.