Regenerative Cell Therapies in the News
Clinical Evidence
- Slynarski K, et al: Treatment of Osteoarthritis: Adipose Derived Stem Cell & PRP Therapy. Sportärztezeitung March 2017
- Dai WL, et al: Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. Arthroscopy: The Journal of Arthroscopic and Related Surgery. 2016.
- Michalek J, et al: Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis. Cell Transplantation. 2015
- Nguyen P, et al: Comparative Clinical Observation of Arthroscopic Microfracture in the Presence and Absence of a Stromal Vascular Fraction Injection for Osteoarthritis. Stem Cells Translational Medicine. 2016;5:1-9
- Mazzocca A, et al: The positive effects of different platelet-rich plasma methods on human muscle, bone and tendon cells. The American Journal of Sports Medicine. 2012; 40(8): 1742-9.
- Smith PA: Intra-articular Autologous Conditioned Plasma injections provide safe and efficacious treatment for knee osteoarthritis. The American Journal of Sports Medicine. 2016; 44(4): 884-91.
- Centeno C, et al: A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomised controlled trial with two-year follow-up. Journal of Translational Medicine. 2018; 16:355
- Bansal H, et al: Intra-articular injection in the knee of adipose-derived stromal cells (stromal vascular fraction) and platelet-rich plasma for osteoarthritis. Journal of Translational Medicine. 2017; 15:14
- Kim J, Lee G, Jung G et al. Outcome of Autologous Bone Marrow Aspirates Concentrate Injection in Degenerative
Arthritis of the Knee. Eur J Orthop Surg Traumatol. 2014;24(1):505–1511. - Oliver K, Alexander RW. Combination of Autologous Adipose-Derived Tissue Stromal Vascular Fraction Plus High Density Platelet-Rich Plasma or Bone Marrow Concentrates in Achilles Tendon Tears. J of Prolotherapy. 2013;5:895-912
- Patel S, Dhillon S, Aggarwal S, Marwaha N, Jain A. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med. 2013;41(2):356-64.
- Oliver K, Bayes M, Crane D, C Pathikonda. Clinical Outcome of Bone Marrow Concentrate in Knee Osteoarthritis. Journal of Prolotherapy. 2015
- Görmeli G, Görmeli C, et al: Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double‑blind, placebo‑controlled trial. Knee Surg Sports Traumatol Arthroscopy. 2015
- Kuan-Yu Lin, et al: Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 35, No 1 (January), 2019: pp 106-117
- D. U. Jeong, et al: Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy. BioMed Research International Volume 2014, Article ID 249498, 15 pages
- Rachad Zayni, et al: Platelet-rich plasma as a treatment for chronic patellar tendinopathy: comparison of a single versus two consecutive injections. Muscles, Ligaments and Tendons Journal 92 2015;5 (2):92-98
- Ford RD, William P, Lineberry S, Luce P. A retrospective comparison of the management of recalcitrantlateral elbow tendinosis: platelet-rich plasma injections versus surgery. Hand (2015) 10:285–291
- Lebiedziński R, et al: A randomized study of autologous conditioned plasma and steroid injections in the treatment of lateral epicondylitis. International Orthopaedics (SICOT) 2015
- Jain K, Murphy P, Clough T. Platelet rich plasma versus corticosteroid injection for plantar fasciitis: A comparative study. The International Journal of Clinical Foot Science. (2015)
- Deans V, Miller A, Ramos J. A Prospective Series of Patients with Chronic Achilles Tendinopathy Treated with Autologous-conditioned Plasma Injections Combined with Exercise and Therapeutic Ultrasonography. The Journal of Foot & Ankle Surgery. 2012
- Hernigou P, et al: Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. Journal of Bone Joint Surgery Am. 2005 July;87(7):1430-7.
- Singh AK, et al: Percutaneous autologous bone marrow injections for delayed or non-union of bones. Journal of Orthopaedic Surgery. 2013 April;21(1):60-4.
- Desai P, et al: Bone Mesenchymal Stem Cells with Growth Factors Successfully Treat Nonunions and Delayed Unions. HSSJ (2015) 11:104–111
- Madry H, et al: Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects. Stem Cells International. Volume 2017, Article ID 1609685
- Darrow M, et al: Short-Term Outcomes of Treatment of Hip Osteoarthritis With 4 Bone Marrow Concentrate Injections: A Case Series. Clinical Medicine Insights: Case Reports. 2018 Volume 11: 1–5
- Shaw B, et al: Short-Term Outcomes in Treatment of Knee
Osteoarthritis With 4 Bone Marrow Concentrate Injections. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders. 2018 Volume 11: 1–6 - Gorelick L, et al: Results of treatment of greater trochanteric pain syndrome in diabetic patients by single Hyaluronic Acid injection. International Journal of Humanities, Arts, Medicine and Sciences (BEST: IJHAMS). ISSN 2348-0521 Vol. 2, Issue 9, Sep 2014, 53-60
- Pogliacomi F, et al: When is indicated viscosupplementation in hip osteoarthritis? Acta Biomed. 2019; Vol. 90, Supplement 1: 67-74
- Rivera F. Single intra-articular injection of high molecular weight hyaluronic acid for hip osteoarthritis. Journal Orthopaedic Traumatology. Sept 2015
- Altman R, et al: Association between Hyaluronic Acid Injections and Time-to-Total Knee Replacement Surgery. Journal of Knee Surgery. October 2015
- Halpern B, et al: Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Clinical Journal of Sports Medicine. 2013; 23(3):238-9.
- Farr J, Cohen SB. Expanding Applications of the Subchondroplasty Procedure for Treatment of Bone Marrow Lesions Observed on Magnetic Resonance Imaging. Oper Tech Sports Med 2013; 21:138-143
- Frobell RB, Roos HP, Roos EM, Hellio Le Graverand MP, Buck R, Tamez-Pena J, Totterman S, Boegard T, Lohmander LS. The acutely ACL injured knee assessed by MRI: are large volume traumatic bone marrow lesions a sign of severe compression injury? Osteoarthritis and Cartilage 2008; 16:829-836
- Rosen MA, Jackson DW, Berger PE. Occult Osseous lesions Documented by Magnetic Resonance Imaging Associated with Anterior Cruciate Ligament Ruptures. Arthroscopy: The Journal of Arthroscopic and Related Surgery 1991; 7(1):45-51
- Cohen SB, Sharkey PF. Subchondroplasty for Treating Bone Marrow Lesions. J Knee Surg. 2016; 29(7):555-563
- Roemer FW, Neogi T, Nevitt MC, et al. Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study. Osteoarthritis Cartilage 2010; 18(1):47–53
- Wluka AE, Wang Y, Davies-Tuck M, English DR, Giles GG, Cicuttini FM. Bone marrow lesions predict progression of cartilage defects and loss of cartilage volume in healthy middle-aged adults without knee pain over 2 yrs. Rheumatology (Oxford) 2008; 47(9):1392–1396
- Felson DT, Chaisson CE, Hill CL, et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 2001; 134(7):541–549
- Tanamas SK, Wluka AE, Pelletier JP, et al. Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study. Rheumatology (Oxford) 2010; 49(12):2413–2419
- Niall DM, Bobic VB. Bone Bruising and Bone Marrow Edema Syndromes: Incidental Radiological Findings or Harbingers of Future Joint Degeneration? International Society of Arthroscopy, Knee Surgery, and Orthopaedic Sports Medicine.
- Smith RC, Constable RT, Reinhold C, McCauley T, Lange RC, McCarthy S. Fast Spin Echo STIR Imaging. Journal of Computer Assisted Tomography. 1994; 18(2):209-213
- Centeno C, Pitts J, Al-Sayegh H, Freeman M. Efficacy of autologous bone marrow concentrate for knee osteoarthritis with and without adipose graft. Biomed Research International. 2014;14:1-9.
- Filardo G, Madry H, Jelic M, Roffi A, Cuccchiarini M, Kon E. Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical applications in orthopaedics. Knee Surg Sports Traumatol Arthrosc. 2013;21:1717-1929.
- Huang J, Zuk P, Jones N, et al. Chondrogenic potential of multipotential cells from human adipose tissue. Plast. Reconstr. Surg. 2004;113(2):585-594.
- Kapoor M, Martel-Pelletierm J, Lajeunesse D, Pelletier J, Fahmi H. Role of pro-inflammatory cytokines in the pathophysiology of osteoarthritis. Nature Reviews Rheumatology. 2011;7:33-42.